TH5487 ≥97%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87645-5mg |
≥97% | ￥600.00 |
货期：2-3天 | - | - | - | - |
|
S87645-10mg |
98.68% | ￥960.00 |
3 | - | - | - | - |
|
S87645-25mg |
98.68% | ￥1920.00 |
4 | - | - | - | - |
|
S87645-100mg |
≥97% | ￥5440.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | TH5487是 8-oxoguanine DNA glycosylase 1 (OGG1) 的选择性活性位点抑制剂，IC50为342 nM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | OGG1(Cell-free assay):342 nM | ||||||||||||||||||||
| 体外研究： | TH5487 increases the melting temperature of OGG1 in human cells.TH5487 impaires repair of genomic 8-oxoG induced by KBrO3.TH5487 preventes OGG1 binding to its genomic substrate in living cells | ||||||||||||||||||||
| 体内研究： | To assess whether TH5487 could down-regulate chemotactic (C-C and C-X-C) mediators in vivo, we challenge mouse lungs with TNFα and profile the gene expression of proinflammatory mediators. TH5487 is efficacious in vivo, suggesting that the compound could be used for the treatment of inflammatory conditions. | ||||||||||||||||||||
| 细胞实验： | Cell lines: HEK 293T cells Wild-type, HEK 293T cells OGG1-KO, MLE12, hSAECs Concentrations: 5 μM Incubation Time: 1 h Method: -- | ||||||||||||||||||||
| 动物实验： | Animal Models: mice (50% female and 50% male) of which lungs are TNFα-challenged intranasally (20 ng/ml) Dosages: 30 mg/kg Administration: IP | ||||||||||||||||||||
| 参考文献： | 1. Visnes T, et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(2篇)
2. [IF=6.7] Jingfang Zhao et al."Single-Cell Super-Resolution Quantification of Oxidative DNA Damage via Aptamer-Assisted DNA-PAINT."ANALYTICAL CHEMISTRY.2025;XXXX(XXX):XXX-XXX
1. [IF=4.2] Yun Qiu et al."Repair-driven DNA tetrahedral nanomachine combined with DNAzyme for 8-oxo guanine DNA glycosylase activity assay, drug screening and intracellular imaging."ANALYST.2023 Dec;:
质检证书(COA)
如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?
如何获取质检证书(COA)
危险品化学品经营许可证（不带存储）
营业执照(三证合一)