货号	规格	价格	上海	北京	珠海	重庆	武汉
S87665-5mg买3赠1	98.80%	￥150.00 S87665-5mg ￥150.00 现货（买3赠1）	4 4	-	-	-	-
S87665-10mg买3赠1	98.80%	￥280.00 S87665-10mg ￥280.00 现货（买3赠1）	4 4	-	-	-	-
S87665-25mg买3赠1	98.80%	￥540.00 S87665-25mg ￥540.00 现货（买3赠1）	7 7	-	-	-	-
S87665-100mg	≥98%	￥1390.00 S87665-100mg ￥1390.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

CADD522 is a RUNX2-DNA binding inhibitor (downregulates RUNX2-mediated transcription of downstream target genes), with an IC50 of 10 nM. CADD522 inhibits primary tumor growth and experimental metastasis of tumor cells in the lungs of immune-compromised mice. CADD522 can be used in study of cancer

靶点：

RUNX2-DNA binding

体内研究：

CADD522 (1, 5 and 20 mg/kg; i.p.; twice a week for 45 days) delays the onset of the tumors and suppresses tumor growth in mice.CADD522 (10 mg/kg; i.p.; twice a week for 11 days) suppresses tumor metastasis and inhibits expression of Ki-67 in mice. Animal Model: Female mice (6-week-old; MMTV-PyMT transgenic model). Dosage: 1, 5 and 20 mg/kg Administration: Intraperitoneal injection; twice a week for 45 days. Result: Delayed the onset of the tumors, delayed tumor development and reduced tumor burden in transgenic MMTV-PyMT mice.Reduced the tumor weight in mice.

参考文献：

1. Kim MS, et al. Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity. Oncotarget. 2017 Aug 10;8(41):70916-70940. 2. Kim MS, et al. Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis. Oncotarget. 2020 Oct 27;11(43):3863-3885.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.066 ml	15.329 ml	30.659 ml
5 mM	0.613 ml	3.066 ml	6.132 ml
10 mM	0.307 ml	1.533 ml	3.066 ml
50 mM	0.061 ml	0.307 ml	0.613 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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