货号	规格	价格	上海	北京	珠海	重庆	武汉
S87666-2mg买3赠1	97.90%	￥580.00 S87666-2mg ￥580.00 现货（买3赠1）	4 4	-	-	-	-
S87666-5mg买3赠1	97.90%	￥990.00 S87666-5mg ￥990.00 现货（买3赠1）	6 6	-	-	-	-
S87666-25mg	97.90%	￥2520.00 S87666-25mg ￥2520.00 现货	10 10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S87666-2mg买3赠1

97.90%

￥580.00

S87666-5mg买3赠1

97.90%

￥990.00

S87666-25mg

97.90%

￥2520.00

产品描述：

PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε)

靶点：

human PKCβ1:21 nM (IC50);human PKCβ2:5 nM (IC50);PKCα:331 nM (IC50);Apoptosis; PKC

体外研究：

PKCβ inhibitor 1 (0-30 μM; 48 hours) suppresses tumor cell proliferation in a time- and dose-dependent manner. PKCβ inhibitor 1 (14 μM; 2-48 hours) induces apoptosis in 2F7 cells. PKCβ inhibitor 1 (15 μM; 2-48 hours) inhibits cell cycle progression in 2F7 and BCBL-1 cells. PKCβ (15 or 14 μM, respectively; 2-48 hours) inhibitor 1 reduces the expression of phospho-PKCβ in BCBL-1 and 2F7 cells. PKCβ inhibitor 1(0-48 hours) suppresses GSK3β, mTOR, and S6 phosphorylation. Cell Proliferation Assay Cell Line: 2F7, BCBL-1 cells Concentration: 0, 5, 10, 20, and 30 μM Incubation Time: 48 hours Result: A dose-dependent reduction in viability of the 2F7 and BCBL-1 cells starting at 5 μM and increasing with elevated inhibitor concentration. Apoptosis Analysis Cell Line: 2F7 cells Concentration: 14 μM Incubation Time: 2-48 hours Result: Apoptotic induction in 2.1% of the 2F7 cells above background after 2 hours of treatment, increasing through 48 hours of treatment. Cell Cycle Analysis Cell Line: BCBL-1 Cells Concentration: 15 μM (the IC50) Incubation Time: 2-48 hours Result: Inhibits cell cycle progression in 2F7 and BCBL-1 cells. Western Blot Analysis Cell Line: BCBL-1 and 2F7 cell lines Concentration: 15 or 14 μM (at the IC50 respectively) Incubation Time: 2-48 hours Result: The expression of phospho-PKCβ in BCBL-1 and 2F7 cells reduced.

参考文献：

1. Tanaka M, et al. Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4. 2. Saba NS, et al. Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cells. J Investig Med. 2012 Jan;60(1):29-38

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.43 ml	12.152 ml	24.304 ml
5 mM	0.486 ml	2.43 ml	4.861 ml
10 mM	0.243 ml	1.215 ml	2.43 ml
50 mM	0.049 ml	0.243 ml	0.486 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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