货号	规格	价格	上海	北京	珠海	重庆	武汉
S87674-5mg买3赠1	≥98%	￥400.00 S87674-5mg ￥400.00 现货（买3赠1）	45 >10	-	-	-	-
S87674-10mg买3赠1	98.98%	￥590.00 S87674-10mg ￥590.00 现货（买3赠1）	25 1 >10	-	-	-	-
S87674-25mg买3赠1	≥98%	￥940.00 S87674-25mg ￥940.00 现货（买3赠1）	9 9	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S87674-5mg买3赠1

≥98%

￥400.00

>10

S87674-10mg买3赠1

98.98%

￥590.00

>10

S87674-25mg买3赠1

≥98%

￥940.00

产品描述：

SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties

靶点：

IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)

体外研究：

SC-26196 (200?nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells. Cell Proliferation Assay Cell Line: PBMCs and Jurkat cells Concentration: 200 nM Incubation Time: 96 hours for PBMCs; 144 hours for Jurkat cells Result: Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.Did not alter cell proliferation significantly in Jurkat cells.

体内研究：

SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme. Animal Model: Male mice (12- or 15-week-old) Dosage: 0, 10, 30, and 100 mg/kg per day Administration: Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day. Result: Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.

参考文献：

1. Obukowicz MG, et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther. 1998 Oct;287(1):157-66. 2. Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5;9:432. 3. Hargrave-Barnes KM, et al. Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008 Oct;16(10):2245-52. 4. Zhang L, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.361 ml	11.805 ml	23.61 ml
5 mM	0.472 ml	2.361 ml	4.722 ml
10 mM	0.236 ml	1.18 ml	2.361 ml
50 mM	0.047 ml	0.236 ml	0.472 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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