货号	规格	价格	上海	北京	珠海	重庆	武汉
S87675-5mg买3赠1	99.20%	￥450.00 S87675-5mg ￥450.00 现货（买3赠1）	8 8	-	-	-	-
S87675-25mg买3赠1	99.20%	￥1090.00 S87675-25mg ￥1090.00 现货（买3赠1）	6 6	-	-	-	-
S87675-100mg买3赠1	99.20%	￥3750.00 S87675-100mg ￥3750.00 现货（买3赠1）	2 2	-	-	-	-

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产品描述：

LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors

靶点：

Survivin

体外研究：

LQZ-7I (10 µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin. Western Blot Analysis Cell Line: PC-3 or C4-2 cells Concentration: 10 µM Incubation Time: 0-6 hours Result: Reduced the expression of survivin.

体内研究：

LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice. Animal Model: 6-week old male NSG mice Dosage: 100 mg/kg; 200 µL vehicle (90% corn oil/10% DMSO) Administration: Oral gavage every other day for a total of ten treatments Result: Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.

参考文献：

1. Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.871 ml	14.353 ml	28.707 ml
5 mM	0.574 ml	2.871 ml	5.741 ml
10 mM	0.287 ml	1.435 ml	2.871 ml
50 mM	0.057 ml	0.287 ml	0.574 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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