货号	规格	价格	上海	北京	珠海	重庆	武汉
S87679-5mg买3赠1	99.90%	￥240.00 S87679-5mg ￥240.00 现货（买3赠1）	5 5	-	-	-	-
S87679-10mg	99.90%	￥390.00 S87679-10mg ￥390.00 现货	7 7	-	-	-	-
S87679-25mg	99.90%	￥770.00 S87679-25mg ￥770.00 现货	4 4	-	-	-	-
S87679-100mg	≥98%	￥2240.00 S87679-100mg ￥2240.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity

靶点：

IC50: 70 nM (GPR4);GPR

体内研究：

NE 52-QQ57 (Compound 13) shows a significant anti-inflammatory effect in the rat antigen induced arthritis model after oral administration at 30 mg/kg bid for 20 days. NE 52-QQ57 (30 mg/kg bid po for 4 days) also prevents angiogenesis in the mouse chamber model as well as pain as demonstrated in the rat complete Freund’s adjuvant model. Animal Model: Female FVB mice (8-10 weeks) Dosage: 30 mg/kg Administration: Oral, 4 days, bid Result: Treatment at 30 mg/kg p.o. bid starting on day 0, the day of the chamber implantation, showed a statistically significant reduction (46.8±10.6%) of tissue growth by day 4. The blood levels of 13 on day 4 at 2 and 16 h after compound application in this model were 9.03±2.87 and 0.09±0.06 μM.

参考文献：

1. Velcicky J, et al. Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem. 2017 May 11;60(9):3672-3683. 2. Hosford PS, et al. CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology. 2018 Aug;138:381-392.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.401 ml	12.004 ml	24.008 ml
5 mM	0.48 ml	2.401 ml	4.802 ml
10 mM	0.24 ml	1.2 ml	2.401 ml
50 mM	0.048 ml	0.24 ml	0.48 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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