货号	规格	价格	上海	北京	珠海	重庆	武汉
S87682-5mg买3赠1	99.50%	￥425.00 S87682-5mg ￥425.00 现货（买3赠1）	5 5	-	-	-	-
S87682-10mg买3赠1	99.50%	￥646.00 S87682-10mg ￥646.00 现货（买3赠1）	5 5	-	-	-	-
S87682-25mg促销	99.50%	￥1270.00 ￥1010.00 S87682-25mg ￥1010.00 现货	5 5	-	-	-	-
S87682-50mg促销	≥98%	￥2210.00 ￥1760.00 S87682-50mg ￥1760.00 2-3天	0 货期：2-3天	-	-	-	-
S87682-100mg促销	≥98%	￥3820.00 ￥3050.00 S87682-100mg ￥3050.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments).

靶点：

EC50: 3.4 μM (α7 nAChR, in oocyte experiments);AChR

体外研究：

NS 1738 acts by increasing the peak amplitude of acetylcholine (ACh)-evoked currents at all concentrations; thus, it increased the maximal efficacy of ACh. Plotting peak current amplitude against the logarithm of the NS 1738 concentration used for preincubation reveals a sigmoidal concentration-response relationship that is well fit by the Hill equation (EC50=3.4 μM). Under similar experimental conditions, NS 1738 shows comparable efficacy and potency at the rat α7 nAChR (EC50=3.9 μM)

体内研究：

To estimate the ability of NS 1738 to permeate the blood-brain barrier, rats are administered 10 mg/kg NS 1738 intraperitoneally. Peak brain concentrations are measured approximately 30 min after injection, and they amount to ~80 ng/mL (~200 nM) at this dose. The ratio between the amount of compound entering the brain and that in plasma is AUCbrain/AUCplasma=0.50. The half-life in plasma is estimated to 42 min. Incubation of NS1738 with isolated liver microsomes in vitro indicates that approximately 60 and 75% of NS 1738 is metabolized via the cytochrome P450 system in mouse and rat, respectively, within 1 h. Adult rats administered NS 1738 at 10 and 30 mg/kg i.p. immediately following the initial exposure to a juvenile rat (T1) display significant decreases in the investigative duration of a subsequent exposure to the same juvenile (T2) 2 h later (T2/T1 ratio of 0.69±0.13 and 0.61±0.07, respectively)

参考文献：

1. Timmermann DB, et al. An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.739 ml	13.693 ml	27.387 ml
5 mM	0.548 ml	2.739 ml	5.477 ml
10 mM	0.274 ml	1.369 ml	2.739 ml
50 mM	0.055 ml	0.274 ml	0.548 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置