货号	规格	价格	上海	北京	珠海	重庆	武汉
S87683-5mg促销	99.90%	￥150.00 ￥120.00 S87683-5mg ￥120.00 现货	5 5	-	-	-	-
S87683-10mg促销	99.90%	￥280.00 ￥224.00 S87683-10mg ￥224.00 现货	5 5	-	-	-	-
S87683-25mg促销	99.90%	￥480.00 ￥432.00 S87683-25mg ￥432.00 现货	5 5	-	-	-	-
S87683-50mg	≥98%	￥790.00 S87683-50mg ￥790.00 2-3天	0 货期：2-3天	-	-	-	-
S87683-100mg	≥98%	￥1280.00 S87683-100mg ￥1280.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1

靶点：

hPARP-1:7.35 (pIC50);mPARP-2:5.38 (pIC50);PARP

体外研究：

In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pKi value of 7.05[1].BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC50 of 5.75)

体内研究：

BYK204165 is not investigated in vivo because of its short half-time (t1/2) of 23 min measured at rat microsomes in vitro

参考文献：

1. Eltze T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol. 2008 Dec;74(6):1587-98.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.964 ml	19.82 ml	39.64 ml
5 mM	0.793 ml	3.964 ml	7.928 ml
10 mM	0.396 ml	1.982 ml	3.964 ml
50 mM	0.079 ml	0.396 ml	0.793 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

BYK204165

4-[(1-Methyl-1H-Pyrrol-2-yl)Methylene]-1,3(2H,4H)-Isoquinolinedione

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)