| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87694-5mg促销 |
98.70% | ￥1600.00 ￥1280.00 |
4 | - | - | - | - |
|
S87694-10mg促销 |
98.70% | ￥2800.00 ￥2240.00 |
5 | - | - | - | - |
|
S87694-25mg促销 |
98.70% | ￥4400.00 ￥3520.00 |
2 | - | - | - | - |
|
S87694-100mg促销 |
≥98% | ￥12000.00 ￥9600.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects | ||||||||||||||||||||
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| 靶点： | Camptothecins | ||||||||||||||||||||
| 体内研究： | CL2A-SN-38 偶联抗 Trop-2 人源化抗体 hRS7 (腹腔注射，0.2或0.4mg/kg，每周2次，4周) 均能显著抑制人结肠 (COLO 205) 或胰腺小鼠肿瘤异种移植物模型的肿瘤生长 (Capan-1) | ||||||||||||||||||||
| 参考文献： | 1. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. 2. Thomas M Cardillo, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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