货号	规格	价格	上海	北京	珠海	重庆	武汉
S87696-5mg买3赠1	99.00%	￥1420.00 S87696-5mg ￥1420.00 现货（买3赠1）	6 6	-	-	-	-
S87696-10mg买3赠1	99.00%	￥2130.00 S87696-10mg ￥2130.00 现货（买3赠1）	6 6	-	-	-	-
S87696-25mg	≥98%	￥3630.00 S87696-25mg ￥3630.00 2-3天	0 货期：2-3天	-	-	-	-
S87696-100mg	≥98%	￥12000.00 S87696-100mg ￥12000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

NKP-1339 (IT-139; KP-1339) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. NKP-1339 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. NKP-1339 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu

靶点：

Apoptosis;Antibacterial

体内研究：

NKP-1339 (intravenous injection; 30 mg/kg; once a week; 42sdays) combines with the multi-kinase inhibitor sorafenib and exhibits a further anticancer activity when compares to the NKP-1339 treatment alone in Hep3B xenografts grown in Balb/c SCID mice. Animal Model: Hep3B xenograft in Balb/c mice Dosage: 30 mg/kg Administration: Intravenous injection Result: Had synergistic activity of KP1339 with sorafenib in vivo.

参考文献：

1. Robert Trondl, et al. NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application. Chemical Science. Chemical Science 2. Heffeter P, et al. The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo. Eur J Cancer. 2013 Oct;49(15):3366-75.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.991 ml	9.957 ml	19.915 ml
5 mM	0.398 ml	1.991 ml	3.983 ml
10 mM	0.199 ml	0.996 ml	1.991 ml
50 mM	0.04 ml	0.199 ml	0.398 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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