| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87710-5mg买3赠1 |
99.70% | ￥255.00 |
6 | - | - | - | - |
|
S87710-10mg买3赠1 |
99.70% | ￥460.00 |
5 | - | - | - | - |
|
S87710-25mg买3赠1 |
99.70% | ￥1110.00 |
6 | - | - | - | - |
|
S87710-50mg买3赠1 |
99.70% | ￥1600.00 |
3 | - | - | - | - |
|
S87710-100mg买3赠1 |
≥98% | ￥2500.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | EC50: 800 nM (RORγt);ROR | ||||||||||||||||||||
| 体外研究： | SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production | ||||||||||||||||||||
| 参考文献： | 1. Chang MR, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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