| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87732-2mg |
≥98% | ￥600.00 |
货期：3-5天 | - | - | - | - |
|
S87732-5mg |
≥98% | ￥1190.00 |
货期：3-5天 | - | - | - | - |
|
S87732-10mg |
≥98% | ￥1990.00 |
货期：3-5天 | - | - | - | - |
|
S87732-25mg |
≥98% | ￥4390.00 |
货期：3-5天 | - | - | - | - |
|
S87732-50mg |
≥98% | ￥7030.00 |
货期：3-5天 | - | - | - | - |
|
S87732-100mg |
≥98% | ￥11000.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist. | ||||||||||||||||||||
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| 靶点： | MCH1 receptor | ||||||||||||||||||||
| 体外研究： | ALB-127158(a) has high affinity for the MCH1 receptor (7 nM) with good selectivity over a range of other G-protein coupled receptors (GPCRs), ion channels and transporters, including the MCH2 receptor. In vitro functional assays confirmed that ALB-127158(a) is a potent and selective MCH1 receptor antagonist | ||||||||||||||||||||
| 体内研究： | In a mouse diet induced obesity (DIO) model, ALB-127158(a) produces a significant sustained decrease in body weight and food intake in the range of 5-15 mg/kg bid. The weight reduction is predominantly due to a decrease in fat content. In high fat diet (HFD) rats, ALB-127158(a) produces significant weight loss and food reduction at doses as low as 1.25 mg/kg po. Doses > 1.25 mg/kg po produces weight loss > 6%, maximal weight loss of about 10% in rats is observed at 10 mg/kg. Following single and multiple oral administration of ALB-127158(a), ALB-127158(a) is rapidly absorbed (median tmax attains between 1 and 3 h post dose in lean and overweight/obese subjects) with a trend to decrease over dose suggesting a slower absorption rate of ALB-127158(a) at lower doses. After single doses, ALB-127158(a) has a mean half-life (t1/2) of 18 to 21 h. Slightly longer mean t1/2 estimates of approximately 26 h are obtained following multiple dosing in overweight/obese subjects; steady-state plasma ALB-127158(a) is attained within 6 to 8 days of dosing | ||||||||||||||||||||
| 参考文献： | 1. Moore NA, et al. From preclinical to clinical development: the example of a novel treatment for obesity. Neurobiol Dis. 2014 Jan;61:47-54. | ||||||||||||||||||||
| 溶解性： | Soluble in Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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