货号	规格	价格	上海	北京	珠海	重庆	武汉
S87748-2mg买3赠1	98.80%	￥200.00 S87748-2mg ￥200.00 现货（买3赠1）	9 9	-	-	-	-
S87748-5mg买3赠1	98.80%	￥292.00 S87748-5mg ￥292.00 现货（买3赠1）	8 8	-	-	-	-
S87748-10mg买3赠1	98.80%	￥500.00 S87748-10mg ￥500.00 现货（买3赠1）	8 8	-	-	-	-
S87748-50mg促销	98.80%	￥1680.00 ￥1340.00 S87748-50mg ￥1340.00 现货	6 6	-	-	-	-

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产品描述：

ML367 是一种有效的 ATPase family AAA domain-containing protein 5 (ATAD5) 的微摩尔级抑制剂。ML367 会阻断 DNA repair 途径和一般的 DNA damage 反应，包括紫外线刺激的RPA32磷酸化和CHK1磷酸化

靶点：

ATAD5;EpigeneticReaderDomain

体外研究：

ML367 is a probe molecule found to block general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. In this regard, the probe molecule could block DNA repair pathways that function upstream of ATAD5. Additionally, ML367 sensitizes cells possessing a knock-out mutation of the PARP1 gene and as a result may serve as a sensitizer to kill cancer cells defective in the poly (ADP-ribose) polymerase 1 (PARP1)-dependent DNA repair pathway.

细胞实验：

Cell lines: HEK293T cells Concentrations: 5, 10, 20 and 40 μM Incubation Time: 16 h Method: HEK293T cells were transiently transfected with FLAG-tagged ATAD5 and treated with the indicated amount of ML367 for 16 hours in the presence or absence of 20 μM 5-FUrd. ATAD5 protein levels were visualized by western blotting using an antibody against FLAG, and quantified using ImageJ.

参考文献：

1. Jason M. Rohde, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program. Bethesda: National Center for Biotechnology Information (US); 2010–.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.991 ml	14.956 ml	29.911 ml
5 mM	0.598 ml	2.991 ml	5.982 ml
10 mM	0.299 ml	1.496 ml	2.991 ml
50 mM	0.06 ml	0.299 ml	0.598 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ML367

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)