| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87767-1mg买3赠1 |
99.50% | ￥220.00 |
5 | - | - | - | - |
|
S87767-5mg买3赠1 |
99.50% | ￥384.00 |
3 | - | - | - | - |
|
S87767-10mg买3赠1 |
99.50% | ￥720.00 |
7 | - | - | - | - |
|
S87767-25mg买3赠1 |
99.50% | ￥1120.00 |
5 | - | - | - | - |
|
S87767-50mg买3赠1 |
≥98% | ￥2080.00 |
货期：2-3天 | - | - | - | - |
|
S87767-100mg买3赠1 |
≥98% | ￥3270.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. | ||||||||||||||||||||
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| 靶点： | LIMK1:7 nM (IC50);LIMK2:8 nM (IC50);LIMKinase | ||||||||||||||||||||
| 体外研究： | BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2ΔEx2 mouse Schwann cells (MSCs) with an IC50 of ~2 µM. BMS-5 (LIMKi 3) reduces Nf2ΔEx2 MSC viability in a dose-dependent manner with an IC50 of 3.9 µM, but does not significantly reduce the viability of control Nf2flox2/flox2 MSCs at equivalent BMS-5 concentrations. At 10 µM BMS-5, Nf2ΔEx2 MSC viability is 40% compared to 83% for controls | ||||||||||||||||||||
| 体内研究： | BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01) | ||||||||||||||||||||
| 参考文献： | 1. Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. 2. Petrilli A, et al. LIM Domain Kinases as Potential Therapeutic Targets for Neurofibromatosis Type 2.Oncogene. Oncogene. 2014 Jul 3;33(27):3571-82. 3. Lunardi P, et al. Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction. Mol Neurobiol. 2017 Jan 13. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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