货号	规格	价格	上海	北京	珠海	重庆	武汉
S87768-2mg	≥98%	￥150.00 S87768-2mg ￥150.00 现货	5 5	-	-	-	-
S87768-5mg	≥98%	￥190.00 S87768-5mg ￥190.00 现货	6 6	-	-	-	-
S87768-10mg	≥98%	￥350.00 S87768-10mg ￥350.00 现货	5 5	-	-	-	-
S87768-25mg	≥98%	￥460.00 S87768-25mg ￥460.00 现货	6 6	-	-	-	-
S87768-50mg	≥98%	￥850.00 S87768-50mg ￥850.00 2-3天	0 货期：2-3天	-	-	-	-
S87768-100mg	≥98%	￥1500.00 S87768-100mg ￥1500.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM

靶点：

IC50: 7.5 μM (hERG potassium ion channel);PotassiumChannel; Parasite

体外研究：

In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC50s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC50 of 7.5±0.8 μM

体内研究：

In vivo, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED50 and ED90 of 2.8 and 4.7 mg/kg, respectively

参考文献：

1. O'Neill PM, et al. Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. J Med Chem. 2009 Mar 12;52(5):1408-15.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.332 ml	11.661 ml	23.322 ml
5 mM	0.466 ml	2.332 ml	4.664 ml
10 mM	0.233 ml	1.166 ml	2.332 ml
50 mM	0.047 ml	0.233 ml	0.466 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置