| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87840-2mg促销 |
98.40% | ￥100.00 ￥80.00 |
5 | - | - | - | - |
|
S87840-5mg促销 |
98.40% | ￥160.00 ￥128.00 |
6 | - | - | - | - |
|
S87840-10mg促销 |
98.40% | ￥260.00 ￥208.00 |
6 | - | - | - | - |
|
S87840-25mg促销 |
98.40% | ￥470.00 ￥422.00 |
3 | - | - | - | - |
|
S87840-50mg |
≥98% | ￥660.00 |
货期：2-3天 | - | - | - | - |
|
S87840-100mg |
≥98% | ￥1190.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM. | ||||||||||||||||||||
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| 靶点： | IC50: 85 nM (GABAB receptor);GABAReceptor | ||||||||||||||||||||
| 体外研究： | CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively | ||||||||||||||||||||
| 体内研究： | CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats | ||||||||||||||||||||
| 参考文献： | 1. Lanza M, et al. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol. 1993 Jun 24;237(2-3):191-5. 2. Sweeney FF, et al. Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice. Neuropharmacology. 2014 Jun;81:303-10. 3. Kobuchi S, et al. Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats. Clin Exp Pharmacol Physiol. 2015 Mar;42(3):278-86. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | 2-8°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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