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CGP 52432

    
98.40%

CGP 52432

源叶(MedMol)
S87840 一键复制产品信息
139667-74-6
C15H24Cl2NO4P
384.24
4-苄氧基苯基异硫氰酸酯
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S87840-2mg促销
98.40%

¥100.00 ¥80.00

5 - - - -
S87840-5mg促销
98.40%

¥160.00 ¥128.00

6 - - - -
S87840-10mg促销
98.40%

¥260.00 ¥208.00

6 - - - -
S87840-25mg促销
98.40%

¥470.00 ¥422.00

3 - - - -
S87840-50mg
≥98%

¥660.00

货期:2-3天 - - - -
S87840-100mg
≥98%

¥1190.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
靶点: IC50: 85 nM (GABAB receptor);GABAReceptor
体外研究: CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively
体内研究: CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats
参考文献: 1. Lanza M, et al. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol. 1993 Jun 24;237(2-3):191-5. 2. Sweeney FF, et al. Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice. Neuropharmacology. 2014 Jun;81:303-10. 3. Kobuchi S, et al. Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats. Clin Exp Pharmacol Physiol. 2015 Mar;42(3):278-86.
溶解性: Soluble  in  DMSO、H2O
保存条件: 2-8°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.603 ml 13.013 ml 26.025 ml
5 mM 0.521 ml 2.603 ml 5.205 ml
10 mM 0.26 ml 1.301 ml 2.603 ml
50 mM 0.052 ml 0.26 ml 0.521 ml
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参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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