货号	规格	价格	上海	北京	珠海	重庆	武汉
S87850-1mg买3赠1	98.60%	￥245.00 S87850-1mg ￥245.00 现货（买3赠1）	9 9	-	-	-	-
S87850-5mg买3赠1	98.60%	￥520.00 S87850-5mg ￥520.00 现货（买3赠1）	6 6	-	-	-	-
S87850-10mg买3赠1	98.60%	￥820.00 S87850-10mg ￥820.00 现货（买3赠1）	5 5	-	-	-	-
S87850-50mg促销	98.60%	￥2770.00 ￥2210.00 S87850-50mg ￥2210.00 现货	2 2	-	-	-	-

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产品描述：

WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity

靶点：

Retinoic acid receptor;Apoptosis; RetinoidReceptor; Autophagy

体外研究：

WYC-209 (10 μM; 24 hours) is able to inhibit and block growth of TRCs of human tumor cells in culture with a long-lasting effect. Apoptosis Analysis Cell Line: A2780, A549, MCF-7, MDA-MB-435s, A375 cells Concentration: 10 μM Incubation Time: 24 hours Result: TRCs failed to resume growth 5 days after the drug washout.

体内研究：

WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases. Animal Model: Female immune-competent C57BL/6 mice Dosage: 0.022, 0.22 mg/kg Administration: Intravenous injection; once every two days for 25 days Result: Four out of eight mice formed lung metastases at dose of 0.022 mg /kg, only one out of eight mice formed lung metastases at dose of 0.22 mg/kg.

参考文献：

1. Chen J, et al. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nat Commun. 2018 Apr 11;9(1):1406.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.714 ml	13.57 ml	27.141 ml
5 mM	0.543 ml	2.714 ml	5.428 ml
10 mM	0.271 ml	1.357 ml	2.714 ml
50 mM	0.054 ml	0.271 ml	0.543 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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