货号	规格	价格	上海	北京	珠海	重庆	武汉
S87851-1mg买3赠1	99.50%	￥365.00 S87851-1mg ￥365.00 现货（买3赠1）	7 7	-	-	-	-
S87851-5mg买3赠1	99.50%	￥1120.00 S87851-5mg ￥1120.00 现货（买3赠1）	5 5	-	-	-	-
S87851-10mg买3赠1	99.50%	￥1800.00 S87851-10mg ￥1800.00 现货（买3赠1）	6 6	-	-	-	-
S87851-25mg买3赠1	99.50%	￥3260.00 S87851-25mg ￥3260.00 现货（买3赠1）	5 5	-	-	-	-
S87851-50mg	99.50%	￥5130.00 S87851-50mg ￥5130.00 现货	5 5	-	-	-	-

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产品描述：

Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.

靶点：

serotonin:723 nM (IC50);Dopamine Receptor:491 nM (IC50);DopamineReceptor; 5-HTReceptor; Norepinephrine

体内研究：

Ansofaxine rapidly penetrates the rat striatum, converts into desvenlafaxine and exhibits larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of ansofaxine increases the 5-HT, dopamine and norepinephrine levels more than the relative administration of desvenlafaxine. Unlike desvenlafaxine, acute administration of an intravenous ansofaxine solution does not induce the undesirable 90% decrease in extracellular 5-HT levels. The acute administration of ansofaxine shows a capped increase in extracellular 5-HT levels when combined with WAY-100635. Acute and chronic administration of ansofaxine reduces the immobility time more than the relative administration of desvenlafaxine

参考文献：

1. Zhang R, et al. The effects of LPM570065, a novel triple reuptake inhibitor, on extracellular serotonin, dopamineand norepinephrine levels in rats. PLoS One. 2014 Mar 10;9(3):e91775.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.393 ml	11.963 ml	23.925 ml
5 mM	0.479 ml	2.393 ml	4.785 ml
10 mM	0.239 ml	1.196 ml	2.393 ml
50 mM	0.048 ml	0.239 ml	0.479 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

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分子摩尔量

计算重置

Ansofaxine (hydrochloride)