货号	规格	价格	上海	北京	珠海	重庆	武汉
S87854-5mg促销	99.80%	￥160.00 ￥128.00 S87854-5mg ￥128.00 现货	8 8	-	-	-	-
S87854-10mg促销	99.80%	￥298.00 ￥238.00 S87854-10mg ￥238.00 现货	6 6	-	-	-	-
S87854-50mg促销	99.80%	￥1040.00 ￥832.00 S87854-50mg ￥832.00 现货	3 3	-	-	-	-
S87854-100mg	≥98%	￥1620.00 S87854-100mg ￥1620.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

BC-1215 是一种 F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) 的抑制剂，对于IL-1β释放的IC50值为0.9 μg/mL，LC50值为87 μg/ml。BC-1215 通过破坏 TRAF1-6 的稳定性来抑制 Fbxo3-TRAF 激活途径

靶点：

IL-1β release(Cell-free assay):0.9 μg/mL; IL-1β release(Cell-free assay):87 μg/mL(LC50);LigandforE3Ligase

体外研究：

BC-1215, a Fbxo3 inhibitor, inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6 proteins. Also, BC-1215 inhibits LPS-induced secretion of a broad spectrum of TH1 panel cytokines in human PBMC

体内研究：

A small molecule Fbxo3 inhibitor, BC-1215, reduces inflammation by antagonizing actions of Fbxo3 on TRAF–cytokine signaling

细胞实验：

Cell lines: Murine lung epithelial (MLE) cells, PBMC, U937 cells Concentrations: -- Incubation Time: -- Method: Murine lung epithelial (MLE) cells were treated with benzathine or BC-1215 at different concentrations for 16 h. Cells were collected and assayed for TRAF1-6, Fbxl2, Fbxo3, and actin immunoblotting. PBMC were treated with either vehicle or 2 μg/ml LPS for 18 h, some cells were also co-treated with BC-1215 in a dose dependent manner up to 10 μg/ml. 18 h later, cells were collected and processed for TRAF immunoblots. U937 cells were transfected with either empty or Fbxo3 plasmid for 24 h. Cells were also treated with BC-1215 in a dose dependent manner up to 10 μg/ml. 18 h later, cells were collected and processed for TRAF immunoblots. PBMC (0.6 ml at 1.5 x 106/ml) were treated with 2 ug/ml LPS for 16 h with BC-1215 at 10 μg/ml. Cytokine release was monitored by the human cytokine array.

动物实验：

Animal Models: model of a cecal ligation and puncture (CLP)-induced sepsis Dosages: 100 μg Administration: i.p.

参考文献：

1. Bill B Chen, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol. 2013 May;14(5):470-9.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

2-8°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.535 ml	12.674 ml	25.348 ml
5 mM	0.507 ml	2.535 ml	5.07 ml
10 mM	0.253 ml	1.267 ml	2.535 ml
50 mM	0.051 ml	0.253 ml	0.507 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

BC-1215

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)