| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87863-1mg |
98% | ￥319.00 |
10 | - | - | - | - |
|
S87863-5mg |
98% | ￥1120.00 |
10 | - | - | - | - |
|
S87863-10mg |
98% | ￥2040.00 |
8 | - | - | - | - |
|
S87863-25mg |
98% | ￥4540.00 |
5 | - | - | - | - |
|
S87863-50mg |
98% | ￥7180.00 |
2 | - | - | - | - |
|
S87863-100mg |
98% | ￥12900.00 |
1 | - | - | - | - |
|
| 产品描述： | Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar, an antiplatelet agent, interferes with platelet signaling. Atopaxar can be used for the research of atherothrombotic disease | ||||||||||||||||||||
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| 靶点： | PAR-1;Protease-activatedReceptor | ||||||||||||||||||||
| 体内研究： | Atopaxar (30-100 mg/kg; p.o.) causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model. Atopaxar does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg. Animal Model: Guinea pigs, PIT model Dosage: Oral administration Administration: 10 mg/kg, 30 mg/kg, 100 mg/kg Result: Prolonged the time to occlusion by 1.8-fold and 2.4-fold at 30 mg/kg and 100 mg/kg, respectively, compared with controls. | ||||||||||||||||||||
| 参考文献： | 1. Chris Dockendorff, et al. Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor. ACS Med Chem Lett. 2012 Mar 8; 3(3): 232–237. 2. Motoji Kogushi, et al. The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs. Eur J Pharmacol. 2011 Apr 25;657(1-3):131-7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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