| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87886-1mg买3赠1 |
99.20% | ￥110.00 |
9 | - | - | - | - |
|
S87886-5mg促销 |
99.20% | ￥160.00 ￥128.00 |
5 | - | - | - | - |
|
S87886-10mg促销 |
99.20% | ￥280.00 ￥224.00 |
5 | - | - | - | - |
|
S87886-25mg促销 |
99.20% | ￥640.00 ￥512.00 |
5 | - | - | - | - |
|
S87886-50mg促销 |
≥98% | ￥1100.00 ￥880.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | (1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity | ||||||||||||||||||||
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| 靶点： | PLK3:0.6 nM (IC50);PLK | ||||||||||||||||||||
| 体内研究： | (1E)-CFI-400437 (25 mg/kg; intraperitoneal injection; daily for 21 days) dihydrochloride shows effective in a mouse xenograft model of tumor growth[1].The plasma levels of (1E)-CFI-400437 (50 mg/kg; IP; mice) dihydrochloride shows a Cmax of 92 ng/mL and AUC of 190 ng•h/mL, respectively. The mouse plasma protein binding measurement for (1E)-CFI-400437 is 99%, i.e., unbound compound in plasma is 1%. Animal Model: 6-8 week old female CB-17 SCID mice (MDA-MB-468 mouse xenograft model) Dosage: 25 mg/kg Administration: Intraperitoneal injection; daily for 21 days Result: Effective in a mouse xenograft model of tumor growth. In this study, (1E)-CFI-400437 is weighed and suspended in PEG400:water (30:70) and sonicated at rt for 30 min. The compound is dispensed in aliquots and stored at −20 C° for the duration of the study, and each aliquot was thawed at room temperature before each dose. | ||||||||||||||||||||
| 参考文献： | 1. Laufer R, et al. The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents. J Med Chem. 2013;56(15):6069-6087. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京