| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87889-1mg促销 |
≥98% | ￥800.00 ￥630.00 |
10 | - | - | - | - |
|
S87889-5mg促销 |
≥98% | ￥2780.00 ￥2220.00 |
10 | - | - | - | - |
|
S87889-10mg促销 |
≥98% | ￥4130.00 ￥3300.00 |
10 | - | - | - | - |
|
S87889-25mg促销 |
≥98% | ￥6580.00 ￥5260.00 |
10 | - | - | - | - |
|
S87889-50mg促销 |
≥98% | ￥8900.00 ￥7110.00 |
7 | - | - | - | - |
|
S87889-100mg促销 |
≥98% | ￥11900.00 ￥9510.00 |
3 | - | - | - | - |
|
| 产品描述： | GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | PI3Kα:3.5 nM (IC50);PI3Kβ:25 nM (IC50);PI3Kδ:5.2 nM (IC50);PI3Kγ:15 nM (IC50);mTOR:750 nM (IC50);PI3K | ||||||||||||||||||||
| 参考文献： | 1. Daniel P Sutherlin, et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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