货号	规格	价格	上海	北京	珠海	重庆	武汉
S87891-5mg促销	98%	￥400.00 ￥360.00 S87891-5mg ￥360.00 现货	9 9	-	-	-	-
S87891-10mg促销	98%	￥600.00 ￥540.00 S87891-10mg ￥540.00 现货	10 10	-	-	-	-
S87891-25mg促销	98%	￥1100.00 ￥990.00 S87891-25mg ￥990.00 现货	10 10	-	-	-	-
S87891-50mg促销	98%	￥1800.00 ￥1620.00 S87891-50mg ￥1620.00 现货	10 10	-	-	-	-
S87891-100mg促销	98%	￥2500.00 ￥2250.00 S87891-100mg ￥2250.00 现货	9 9	-	-	-	-
S87891-250mg促销	98%	￥4400.00 ￥3960.00 S87891-250mg ￥3960.00 现货	5 5	-	-	-	-

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产品描述：

JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively

靶点：

VEGFR-2:40 nM (IC50);RET:180 nM (IC50);c-Kit:500 nM (IC50);VEGFR; c-RET; c-Kit

体内研究：

JNJ-38158471 (10 or 100 mg/kg; p.o.; once-daily) inhibits VEGF-induced corneal neovascularization. JNJ-38158471 (10-200 mg/kg; p.o.) inhibits the growth of human tumor xenografts in a dose-dependent manner in both A431 and HCT116 models. JNJ-38158471 treatment is well tolerated, following continuous administration for 24 days, body weights were comparable with control animals. JNJ-38158471 (100 mg/kg; p.o.; once-daily) treatment shows statistically signiﬁcant activity compare with vehicle treat animals. The body weights of both JNJ-38158471-treated and vehicle-treated groups were comparable at study end. Animal Model: Female C57BL/6J mice are implanted with rhVEGF165 Dosage: 10 or 100 mg/kg Administration: Daily oral administration for 6 days Result: Caused a marked and apparently dose-dependent inhibition of VEGF-dependent blood vessel formation (100 mg/kg, resulted in 83% inhibition; 10 mg/kg, resulted in 15% inhibition).

参考文献：

1. Kenneth RL, et, al. A Highly Selective, Orally Bioavailable, Vascular Endothelial Growth Factor receptor-2 Tyrosine Kinase Inhibitor Has Potent Activity in Vitro and in Vivo. Angiogenesis. 2009; 12(3): 287-96.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.741 ml	13.707 ml	27.413 ml
5 mM	0.548 ml	2.741 ml	5.483 ml
10 mM	0.274 ml	1.371 ml	2.741 ml
50 mM	0.055 ml	0.274 ml	0.548 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

CS-2660 (JNJ-38158471)

(E)-1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)