货号	规格	价格	上海	北京	珠海	重庆	武汉
S87892-2mg买3赠1	99.50%	￥408.00 S87892-2mg ￥408.00 现货（买3赠1）	1 1	-	-	-	-
S87892-5mg买3赠1	99.50%	￥612.00 S87892-5mg ￥612.00 现货（买3赠1）	5 5	-	-	-	-
S87892-10mg买3赠1	99.50%	￥1000.00 S87892-10mg ￥1000.00 现货（买3赠1）	5 5	-	-	-	-
S87892-25mg买3赠1	99.50%	￥2140.00 S87892-25mg ￥2140.00 现货（买3赠1）	6 6	-	-	-	-
S87892-50mg买3赠1	≥98%	￥3400.00 S87892-50mg ￥3400.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S87892-100mg	≥98%	￥5320.00 S87892-100mg ￥5320.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.

靶点：

Toxoplasma;Parasite

体外研究：

MBP146-78 displays a dose-dependent inhibition of T. gondii tachyzoites replicating inside HFFs, with an IC50 of 210 nM. The suppression of lytic parasite growth by MBP146-78 is reversible. Replacement of the medium with medium lacking MBP146-78, after treatment for up to 7 days at 2 μM, results in complete lysis of HFF cell monolayers. MBP146-78 is neither toxic nor inhibitory to proliferating or confluent monolayers of HFFs at concentrations of up to 10 μM

体内研究：

In infected mice that are treated with MBP146-78 at 50 mg/kg twice daily, parasites are undetectable throughout the 10-day treatment period in each of the tissues examined. However, samples from brain, spleen, and lung taken from infected treated mice reveal the presence of parasites after cessation of administration of MBP146-78, indicating that a transient asymptomatic parasite recrudescence occurs in all survivors. The ability of mice to control Toxoplasma infection after MBP146-78 treatment has been terminated suggests that the mouse immune system plays a synergistic role with chemotherapy in controlling the infection

参考文献：

1. Nare B, et al. Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy. Antimicrob Agents Chemother. 2002 Feb;46(2):300-7.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.981 ml	14.907 ml	29.814 ml
5 mM	0.596 ml	2.981 ml	5.963 ml
10 mM	0.298 ml	1.491 ml	2.981 ml
50 mM	0.06 ml	0.298 ml	0.596 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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