| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87912-1mg买3赠1 |
98.80% | ￥330.00 |
6 | - | - | - | - |
|
S87912-5mg促销 |
98.80% | ￥1000.00 ￥800.00 |
5 | - | - | - | - |
|
S87912-10mg促销 |
98.80% | ￥1710.00 ￥1360.00 |
6 | - | - | - | - |
|
S87912-25mg促销 |
98.80% | ￥2910.00 ￥2320.00 |
3 | - | - | - | - |
|
S87912-50mg促销 |
≥98% | ￥4940.00 ￥3950.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM | ||||||||||||||||||||
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| 靶点： | EC50: 193 nM (FXR);FXR; Autophagy | ||||||||||||||||||||
| 体外研究： | LY2562175 promotes transcriptional activation of human FXR in a cell-based co-transfection assay with an EC50 of 193 nM. LY2562175 promotes recruitment of a peptide from the nuclear receptor interaction domain of the coactivator SRC-1 with a relative EC50 of 121 nM and 93.5% efficacy as compare to GW4064 | ||||||||||||||||||||
| 体内研究： | LY2562175 causes a dose-dependent decrease in serum cholesterol and serum triglycerides. At a dose of 10 mg/kg, the decrease in cholesterol with LY2562175 is 80% below vehicle-treated animals, and the decrease in serum triglycerides is 76% from control group. The ED50 for serum cholesterol is determined to be 2 and 3.4 mg/kg for serum triglycerides. Treatment of female ZDF rats with LY2562175 results in a dose dependent lowering of plasma triglycerides in the fasted and nonfasted states. When administered as a fixed dose combination with BRL49653, LY2562175 further lowers fasted and nonfasted plasma triglycerides. FPLC fractionation of the lipoproteins reveals that LY2562175 treatment results in a reduction in vLDL-C and a dramatic increase in HDL-c in this animal model | ||||||||||||||||||||
| 参考文献： | 1. Genin MJ, et al. Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia. J Med Chem. 2015 Dec 24;58(24):9768-72. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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