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CS-2703

    
97.70%

PF-9366

源叶(MedMol)
S87930 一键复制产品信息
72882-78-1
C20H19ClN4
350.84
PF-9366
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S87930-2mg买3赠1
97.70%

¥110.00

8 - - - -
S87930-5mg买3赠1
97.70%

¥150.00

7 - - - -
S87930-10mg买3赠1
97.70%

¥260.00

9 - - - -
S87930-25mg买3赠1
97.70%

¥490.00

4 - - - -
S87930-50mg买3赠1
≥97%

¥860.00

货期:2-3天 - - - -
S87930-100mg
≥97%

¥1240.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM
靶点: IC50: 420 nM (Mat2A) Kd: 170 nM (Mat2A);MethionineAdenosyltransferase(MAT)
体外研究: PF-9366 is a Mat2A inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM.
参考文献: 1. Quinlan CL, et al. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat Chem Biol. 2017 Jul;13(7):785-792.
溶解性: Soluble  in  DMSO
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.85 ml 14.252 ml 28.503 ml
5 mM 0.57 ml 2.85 ml 5.701 ml
10 mM 0.285 ml 1.425 ml 2.85 ml
50 mM 0.057 ml 0.285 ml 0.57 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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