| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87930-2mg买3赠1 |
97.70% | ￥110.00 |
8 | - | - | - | - |
|
S87930-5mg买3赠1 |
97.70% | ￥150.00 |
7 | - | - | - | - |
|
S87930-10mg买3赠1 |
97.70% | ￥260.00 |
9 | - | - | - | - |
|
S87930-25mg买3赠1 |
97.70% | ￥490.00 |
4 | - | - | - | - |
|
S87930-50mg买3赠1 |
≥97% | ￥860.00 |
货期：2-3天 | - | - | - | - |
|
S87930-100mg |
≥97% | ￥1240.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM | ||||||||||||||||||||
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| 靶点： | IC50: 420 nM (Mat2A) Kd: 170 nM (Mat2A);MethionineAdenosyltransferase(MAT) | ||||||||||||||||||||
| 体外研究： | PF-9366 is a Mat2A inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM. | ||||||||||||||||||||
| 参考文献： | 1. Quinlan CL, et al. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat Chem Biol. 2017 Jul;13(7):785-792. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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