| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87935-5mg促销 |
98.90% | ￥290.00 ￥232.00 |
5 | - | - | - | - |
|
S87935-10mg促销 |
98.90% | ￥420.00 ￥336.00 |
6 | - | - | - | - |
|
S87935-25mg促销 |
98.90% | ￥690.00 ￥552.00 |
5 | - | - | - | - |
|
S87935-50mg |
≥98% | ￥980.00 |
货期：2-3天 | - | - | - | - |
|
S87935-100mg |
≥98% | ￥1720.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM). GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 µM). Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue | ||||||||||||||||||||
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| 体内研究： | GSK-114 affords the best balance of specificity and pharmacokinetics, demonstrating useful oral exposure (poDNAUC=0.18, Cmax=130 ng/ml @ 2 mg/kg, t1/2=3.6 hr, rat Fu=20.2%) | ||||||||||||||||||||
| 参考文献： | 1. Lawhorn BG, et al. GSK114: A selective inhibitor for elucidating the biological role of TNNI3K. Bioorg Med Chem Lett. 2016;26(14):3355-3358. 2. Asquith CRM, et al. New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K). Molecules. 2020;25(7):1697. Published 2020 Apr 7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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