| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87939-1mg买3赠1 |
99.40% | ￥180.00 |
9 | - | - | - | - |
|
S87939-5mg买3赠1 |
99.40% | ￥450.00 |
8 | - | - | - | - |
|
S87939-10mg买3赠1 |
99.40% | ￥680.00 |
7 | - | - | - | - |
|
S87939-25mg促销 |
99.40% | ￥1360.00 ￥1080.00 |
5 | - | - | - | - |
|
S87939-50mg促销 |
99.40% | ￥2380.00 ￥1900.00 |
5 | - | - | - | - |
|
| 产品描述： | TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3) | ||||||||||||||||||||
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| 靶点： | pIC50: 6.8 (GluN1/GluN2A NMDA receptor);NMDAR; iGluR | ||||||||||||||||||||
| 体内研究： | TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats | ||||||||||||||||||||
| 参考文献： | 1. Bettini E, et, al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J Pharmacol Exp Ther. 2010 Dec; 335(3): 636-44. 2. Edman S, et, al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep; 63(3): 441-9. 3. Bu F, et, al. NR2A contributes to genesis and propagation of cortical spreading depression in rats. Sci Rep. 2016 Mar 22;6:23576. 4. Shatillo A, et, al. Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI. Neuropharmacology. 2015 Jun; 93:164-70. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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