货号	规格	价格	上海	北京	珠海	重庆	武汉
S87940-5mg	≥98%	￥480.00 S87940-5mg ￥480.00 现货	6 6	-	-	-	-
S87940-10mg	≥98%	￥580.00 S87940-10mg ￥580.00 现货	7 7	-	-	-	-
S87940-25mg	≥98%	￥690.00 S87940-25mg ￥690.00 现货	4 4	-	-	-	-
S87940-50mg	≥98%	￥1180.00 S87940-50mg ￥1180.00 2-3天	0 货期：2-3天	-	-	-	-
S87940-100mg	≥98%	￥1810.00 S87940-100mg ￥1810.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions

靶点：

TRP Channel;TRP/TRPVChannel

体外研究：

ASP7663 concentration dependently increases intracellular Ca2+ concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC50 values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L. ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L

体内研究：

ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice. ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide. ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat. Animal Model: CRD model (colorectal distension in rat). Dosage: 1 and 3 mg/kg. Administration: Orally. Result: Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment.

参考文献：

1. Ryosuke Kojima, et al. Effects of Novel TRPA1 Receptor Agonist ASP7663 in Models of Drug-Induced Constipation and Visceral Pain. Eur J Pharmacol. 2014 Jan 15;723:288-93. 2. Yao Lu, et al. Transient Receptor Potential Ankyrin 1 Activation Within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016 Dec;125(6):1171-1180.

溶解性：

Soluble in DMSO

保存条件：

2-8°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.799 ml	18.993 ml	37.985 ml
5 mM	0.76 ml	3.799 ml	7.597 ml
10 mM	0.38 ml	1.899 ml	3.799 ml
50 mM	0.076 ml	0.38 ml	0.76 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ASP-7663

ASP7663

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)