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ASP-7663

    
≥98%

ASP7663

源叶(MedMol)
S87940 一键复制产品信息
1190217-35-6
C14H14FNO3
263.26
ASP7663
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S87940-5mg
≥98%

¥480.00

6 - - - -
S87940-10mg
≥98%

¥580.00

7 - - - -
S87940-25mg
≥98%

¥690.00

4 - - - -
S87940-50mg
≥98%

¥1180.00

货期:2-3天 - - - -
S87940-100mg
≥98%

¥1810.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions
靶点: TRP Channel;TRP/TRPVChannel
体外研究: ASP7663 concentration dependently increases intracellular Ca2+ concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC50 values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L. ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L
体内研究: ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice. ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide. ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat. Animal Model: CRD model (colorectal distension in rat). Dosage: 1 and 3 mg/kg. Administration: Orally. Result: Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment.
参考文献: 1. Ryosuke Kojima, et al. Effects of Novel TRPA1 Receptor Agonist ASP7663 in Models of Drug-Induced Constipation and Visceral Pain. Eur J Pharmacol. 2014 Jan 15;723:288-93. 2. Yao Lu, et al. Transient Receptor Potential Ankyrin 1 Activation Within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016 Dec;125(6):1171-1180.
溶解性: Soluble  in  DMSO
保存条件: 2-8°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.799 ml 18.993 ml 37.985 ml
5 mM 0.76 ml 3.799 ml 7.597 ml
10 mM 0.38 ml 1.899 ml 3.799 ml
50 mM 0.076 ml 0.38 ml 0.76 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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