货号	规格	价格	上海	北京	珠海	重庆	武汉
S87944-5mg买3赠1	≥98%	￥300.00 S87944-5mg ￥300.00 现货（买3赠1）	200 >10	-	-	-	-
S87944-10mg买3赠1	≥98%	￥550.00 S87944-10mg ￥550.00 现货（买3赠1）	100 >10	-	-	-	-
S87944-25mg买3赠1	≥98%	￥700.00 S87944-25mg ￥700.00 现货（买3赠1）	40 >10	-	-	-	-
S87944-50mg买3赠1	≥98%	￥1200.00 S87944-50mg ￥1200.00 现货（买3赠1）	20 >10	-	-	-	-
S87944-100mg买3赠1	≥98%	￥2000.00 S87944-100mg ￥2000.00 现货（买3赠1）	10 10	-	-	-	-

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产品描述：

The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smooth muscle cell) proliferation and migration in vitro and in neointimal formationin vivo[3]. CGP 53716 inhibited serum-induced cell growth in RASMC (rat aortic smooth muscle cells). And it completely blocked PDGF-BB tyrosine receptor autophosphorylation in RASMC and 3T3 cells, PDGF-BB-induced phosphorylation of mitogen-activated protein kinase at 1 μM in RASMC and inhibited PDGF-BB-induced c-Fos protein expression at 1 μM in RASMC; consistent with inhibition of PDGF-BB-induced DNA synthesis. Further, CGP 53716 inhibited PDGF-BB-, bFGF- and EGF-induced DNA synthesis in a concentration-dependent manner in each cell line. And it showed a 2- to 4-fold selectivity for PDGF-BB-stimulated DNA synthesis over bFGF or EGF in RASMC or 3T3 cells. CGP 53716 inhibited dose dependently tyrosine phosphorylation of both the known PDGFRs: the PDGFR-α and PDGFR-β. After rat carotid artery ballooning injuryin vivo, the migration of alpha-actin-positive cells on the luminal side of internal elastic lamina was decreased with 50 mg/kg/day of CGP 53716 from 38 ± 10 (control group) to 4 ± 2. Intima/media ratio was inhibited by 40% after 14 days in the CGP 53716-treated group (P=0.028) after rat aortic denudation

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.622 ml	13.109 ml	26.217 ml
5 mM	0.524 ml	2.622 ml	5.243 ml
10 mM	0.262 ml	1.311 ml	2.622 ml
50 mM	0.052 ml	0.262 ml	0.524 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

CGP-53716