货号	规格	价格	上海	北京	珠海	重庆	武汉
S87958-5mg买3赠1	98.20%	￥510.00 S87958-5mg ￥510.00 现货（买3赠1）	6 6	-	-	-	-
S87958-10mg买3赠1	98.20%	￥820.00 S87958-10mg ￥820.00 现货（买3赠1）	7 7	-	-	-	-
S87958-25mg买3赠1	98.20%	￥1640.00 S87958-25mg ￥1640.00 现货（买3赠1）	6 6	-	-	-	-
S87958-100mg买3赠1	≥98%	￥4190.00 S87958-100mg ￥4190.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke

靶点：

Aquaporin-4 (AQP4);Aquaporin

体内研究：

AER-271 is converted in vivo to AER-270 by endogenous phosphatases. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. AER-271 reduces cerebral edema and improves neurological outcomes in rodent ischemic stroke models. Mice treated with AER-271 (5 mg/kg; i.p. injection) show improved outcomes and reduced cerebral edema in a model of ischemic stroke. Animal Model: Male mice (C57BL/6J, 8-12 week-old, 25-30 g) Dosage: 5 mg/kg Administration: Treated by i.p. injection Result: Had better outcomes with an average neurological score of 0.89±0.31 compared with control mice receiving vehicle had an average neurological score of 2.50±0.62.

参考文献：

1. Wallisch JS, et al. The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Pediatr Res. 2019 Mar;85(4):511-517. 2. Farr GW, et al. Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury. Neuroscience. 2019 Apr 15;404:484-498.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.157 ml	10.784 ml	21.568 ml
5 mM	0.431 ml	2.157 ml	4.314 ml
10 mM	0.216 ml	1.078 ml	2.157 ml
50 mM	0.043 ml	0.216 ml	0.431 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

AER-271

AER-271 (AER271)

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)