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BMS-986205

    
99.80%

BMS-986205

源叶(MedMol)
S87963 一键复制产品信息
1923833-60-6
C24H24ClFN2O
410.9115632
Linrodostat
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S87963-1mg买3赠1
99.80%

¥130.00

>10 - - - -
S87963-5mg买3赠1
99.80%

¥390.00

>10 - - - -
S87963-10mg买3赠1
99.80%

¥670.00

7 - - - -
S87963-25mg买3赠1
99.80%

¥1140.00

3 - - - -
S87963-50mg买3赠1
≥98%

¥1820.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers
靶点: IDO1:1.1 nM (IC50);IDO; Indoleamine2,3-Dioxygenase(IDO)
体外研究: Linrodostat (0.01-100 μM; 72 hours; SKOV-3 and Jurkat clone E6-1 cells) treatment reduces the number of viable cells compared with the non-treated control. Linrodostat also induces cell death at much lower concentrations and its IC50 is 6.3 μM. Cell Viability Assay Cell Line: SKOV-3 and Jurkat clone E6-1 cells Concentration: 0.01-100 μM Incubation Time: 72 hours Result: Reduced the number of viable cells compared with the non-treated control and induced cell death at much lower concentrations.
参考文献: 1. Richards T, et al. Cell based functional assays for IDO1 inhibitor screening and characterization. Oncotarget. 2018 Jul 20;9(56):30814-30820. 2. Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.434 ml 12.168 ml 24.336 ml
5 mM 0.487 ml 2.434 ml 4.867 ml
10 mM 0.243 ml 1.217 ml 2.434 ml
50 mM 0.049 ml 0.243 ml 0.487 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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