| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87963-1mg买3赠1 |
99.80% | ￥130.00 |
>10 | - | - | - | - |
|
S87963-5mg买3赠1 |
99.80% | ￥390.00 |
>10 | - | - | - | - |
|
S87963-10mg买3赠1 |
99.80% | ￥670.00 |
7 | - | - | - | - |
|
S87963-25mg买3赠1 |
99.80% | ￥1140.00 |
3 | - | - | - | - |
|
S87963-50mg买3赠1 |
≥98% | ￥1820.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers | ||||||||||||||||||||
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| 靶点： | IDO1:1.1 nM (IC50);IDO; Indoleamine2,3-Dioxygenase(IDO) | ||||||||||||||||||||
| 体外研究： | Linrodostat (0.01-100 μM; 72 hours; SKOV-3 and Jurkat clone E6-1 cells) treatment reduces the number of viable cells compared with the non-treated control. Linrodostat also induces cell death at much lower concentrations and its IC50 is 6.3 μM. Cell Viability Assay Cell Line: SKOV-3 and Jurkat clone E6-1 cells Concentration: 0.01-100 μM Incubation Time: 72 hours Result: Reduced the number of viable cells compared with the non-treated control and induced cell death at much lower concentrations. | ||||||||||||||||||||
| 参考文献： | 1. Richards T, et al. Cell based functional assays for IDO1 inhibitor screening and characterization. Oncotarget. 2018 Jul 20;9(56):30814-30820. 2. Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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