| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87964-1mg促销 |
≥98% | ￥170.00 ￥130.00 |
10 | - | - | - | - |
|
S87964-5mg促销 |
≥98% | ￥680.00 ￥540.00 |
10 | - | - | - | - |
|
S87964-10mg促销 |
≥98% | ￥1100.00 ￥870.00 |
8 | - | - | - | - |
|
S87964-25mg促销 |
≥98% | ￥2150.00 ￥1710.00 |
3 | - | - | - | - |
|
S87964-50mg促销 |
≥98% | ￥3440.00 ￥2750.00 |
4 | - | - | - | - |
|
S87964-100mg促销 |
≥98% | ￥5500.00 ￥4390.00 |
2 | - | - | - | - |
|
| 产品描述： | Delpazolid is a novel oxazolidinone antibiotic agent which can inhibit the growth of MSSA and MRSA with a MIC90 of 2 μg/mL for both of them | ||||||||||||||||||||
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| 靶点： | Oxazolidinone;Antibacterial; Antibiotic | ||||||||||||||||||||
| 体外研究： | Delpazolid (LCB01-0371), at concentrations of 1×MIC and 2×MIC, has bacteriostatic activity against MSSA and MRSA after 24 h. At concentrations of 4×MIC and 8×MIC, Delpazolid shows bacteriostatic activity, but there is no regrowth at concentrations of 4×MIC and 8×MIC after 24 h of incubation. The survival of M. abscessus is greatly decreased in the presence of Delpazolid (LCB-0371) (MIC50=1.2 μg/mL). Delpazolid dramatically decreases the number of intracellular mycobacteria present at 2 days after infection at concentrations of 0.1, 1, and 10 μg/mL | ||||||||||||||||||||
| 体内研究： | When administered orally, Delpazolid (LCB01-0371) shows potent protective effects against systemic infections caused by Gram-positive and Gram-negative bacteria. Against infection caused by S. aureus Giorgio (MSSA), the ED50 of Delpazolid is 4.53 mg/kg of body weight. Against S. aureus p125 (MRSA), the ED50 of Delpazolid is 2.96 mg/kg. When Delpazolid (LCB-0371) is administered at 100 mg/kg daily (by gavage), the colony-forming unit (CFU) counts tend to be decreased in the lungs of mice at 7 days after infection | ||||||||||||||||||||
| 参考文献： | 1. Jeong JW, et al. In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. Antimicrob Agents Chemother. 2010 Dec;54(12):5359-62. 2. Kim TS, et al. Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus. Antimicrob Agents Chemother. 2017 Aug 24;61(9). | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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