货号	规格	价格	上海	北京	珠海	重庆	武汉
S87979-1mg促销	99.62%	￥1140.00 ￥1020.00 S87979-1mg ￥1020.00 现货	4 4	-	-	-	-
S87979-5mg	99.62%	￥3370.00 S87979-5mg ￥3370.00 现货	7 0 7	-	-	-	-
S87979-25mg促销	99.62%	￥5990.00 ￥5390.00 S87979-25mg ￥5390.00 现货	2 2	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S87979-1mg促销

99.62%

￥1140.00 ￥1020.00

S87979-5mg

99.62%

￥3370.00

S87979-25mg促销

99.62%

￥5990.00 ￥5390.00

产品描述：

Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect

靶点：

Tetracycline;L-type calcium channel

体内研究：

Minocycline (0-30 mg/kg, orally, daily for 4 weeks) suppresses OVCAR-3 tumor growth in female nude mice[3].Minocycline (IP) is an effective neuroprotective agent in animal models of cerebral ischemia when given in high doses intraperitoneally. Minocycline (0-40 mg/kg, IP, once) significantly attenuats METH-induced hyperlocomotion and the development of behavioral sensitization in mice. Minocycline (3 and 10 mg/kg, IV, once) is effective at reducing infarct size in a Temporary Middle Cerebral Artery Occlusion model (TMCAO). Minocycline (3-10 mg/kg, IV, once) results in serum levels (at 3 mg/kg) similar to that achieved in humans after a standard 200 mg dose. Minocycline attenuates ischemia-induced ventricular arrhythmias in rats. This effect may be associated with activations of PI3K/Akt signaling pathway, mitochondrial KATP channels and L-type Ca2+ channels. Animal Model: Female nude mice (6 weeks old, 9 per group, OVCAR-3 cells were injected s.c. into the left flank of each mouse) Dosage: 10 or 30 mg/kg Administration: Administered orally in the drinking water, initiated on day 8 of cell inoculation, daily for 4 weeks Result: Suppressed OVCAR-3 tumor growth in these female nude mice, and reduced microvessel density.

参考文献：

1. Xu L, et al. Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats. BMC Neurol. 2004 Apr 26;4:7. 2. Zhang L, et al. Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1381-93. 3. Pourgholami MH, et al. Minocycline inhibits growth of epithelial ovarian cancer. Gynecol Oncol. 2012 May;125(2):433-40. 4. Molina-Hernández M, et al. Antidepressant-like actions of minocycline combined with several glutamate antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):380-6. 5. Ritchie DJ, et al. A review of intravenous minocycline for treatment of multidrug-resistant Acinetobacter infections. Clin Infect Dis. 2014 Dec 1;59 Suppl 6:S374-80. 6. Ataie-Kachoie P, et al. Minocycline attenuates hypoxia-inducible factor-1α expression correlated with modulation of p53 and AKT/mTOR/p70S6K/4E-BP1 pathway in ovarian cancer: in vitro and in vivo studies. Am J Cancer Res. 2015 Jan 15;5(2):575-88. 7. Hu X, Wu B, Wang X, Xu C, He B, Cui B, Lu Z, Jiang H. Minocycline attenuates ischemia-induced ventricular arrhythmias in rats. Eur J Pharmacol. 2011 Mar 11;654(3):274-9.

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.186 ml	10.929 ml	21.859 ml
5 mM	0.437 ml	2.186 ml	4.372 ml
10 mM	0.219 ml	1.093 ml	2.186 ml
50 mM	0.044 ml	0.219 ml	0.437 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(8篇)

8. [IF=3.9] Cheng Liang, et al. "Esketamine attenuates bone cancer pain by suppressing MAPK signaling and glial activation in the spinal dorsal horn of rats"Scientific Reports, 2026 Feb;: 7. [IF=13.2] Tengli Zhang et al."Glucosamine-triggered sustainable redox process for efficient degradation of tetracycline antibiotics."CHEMICAL ENGINEERING JOURNAL.2026 Jan;:173062 6. [IF=5.34] Han-Qing Pang et al."An image-based fingerprint-efficacy screening strategy for uncovering active compounds with interactive effects in Yindan Xinnaotong soft capsule."Phytomedicine. 2022 Feb;96:153911 5. [IF=4.225] Li Teng-Fei et al."Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing."Front Pharmacol. 2016 Oct;0:367 4. [IF=4.367] Hui Fan et al."Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression."Neuropharmacology. 2016 Feb;101:98

3. [IF=4.621] Teng-Fei Li et al."Aconitum-Derived Bulleyaconitine A Exhibits Antihypersensitivity Through Direct Stimulating Dynorphin A Expression in Spinal Microglia."J Pain. 2016 May;17:530 2. [IF=5.673] Nian Gong et al."Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity."J Neurosci. 2014 Apr;34(15):5322-5334 1. [IF=5.793] Huang Qian et al."Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models."J Neuroinflamm. 2016 Dec;13(1):1-18

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