货号	规格	价格	上海	北京	珠海	重庆	武汉
S88014-5mg促销	≥98%	￥400.00 ￥360.00 S88014-5mg ￥360.00 现货	10 10	-	-	-	-
S88014-25mg促销	≥98%	￥800.00 ￥720.00 S88014-25mg ￥720.00 现货	8 8	-	-	-	-
S88014-100mg促销	≥98%	￥2430.00 ￥2180.00 S88014-100mg ￥2180.00 现货	2 2	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.

靶点：

5-HT2 Receptor:0.14 nM (Ki);D2 Receptor:0.75 nM (Ki);5-HT1A Receptor:L7.6 (pEC50, h5-HT1A);5-HT1A Receptor:8.08 (pKi, h5-HT1A);a1-adrenergic receptor:0.46 nM (Ki);Histamine H1:1.6 nM (Ki);a2-adrenergic receptor:5.4 nM (Ki);DopamineReceptor; 5-HTReceptor

体内研究：

Ocaperidone shows a potent occupation of 5HT2 receptor via in vivo binding in the frontal cortex of rats with an ED50 of 0.04 mg/kg, and 0.1 4-0.1 6 mg/kg for D2 receptor in the striatum and the nucleus accumbens. Ocaperidone (R 79598) antagonizes dopamine D2 and 5-HT2, and shows a a partial generalization to buspirone with an ED50 of 0.163 mg/kg.

参考文献：

1. Leysen JE, et al. In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Mol Pharmacol. 1992 Mar;41(3):494-508. 2. Cosi C, et al. Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells. Eur J Pharmacol. 2001 Dec 14;433(1):55-62. 3. Rijnders HJ, et al. The discriminative stimulus properties of buspirone involve dopamine-2 receptor antagonist activity. Psychopharmacology (Berl). 1993;111(1):55-61.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.378 ml	11.891 ml	23.782 ml
5 mM	0.476 ml	2.378 ml	4.756 ml
10 mM	0.238 ml	1.189 ml	2.378 ml
50 mM	0.048 ml	0.238 ml	0.476 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

奥卡哌酮

Ocaperidone

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)