货号	规格	价格	上海	北京	珠海	重庆	武汉
S88053-5mg促销	99.80%	￥190.00 ￥152.00 S88053-5mg ￥152.00 现货	5 5	-	-	-	-
S88053-1mg买3赠1	99.80%	￥170.00 S88053-1mg ￥170.00 现货（买3赠1）	9 9	-	-	-	-
S88053-10mg促销	99.80%	￥350.00 ￥280.00 S88053-10mg ￥280.00 现货	6 6	-	-	-	-
S88053-25mg促销	99.80%	￥810.00 ￥648.00 S88053-25mg ￥648.00 现货	6 6	-	-	-	-
S88053-50mg促销	≥98%	￥1610.00 ￥1280.00 S88053-50mg ￥1280.00 2-3天	0 货期：2-3天	-	-	-	-
S88053-100mg促销	≥98%	￥2970.00 ￥2370.00 S88053-100mg ￥2370.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

SU1498是KDR抑制剂，IC50为0.7 μM，可在内皮细胞中刺激磷酸化ERK1/2的累积

靶点：

KDR;VEGFR

细胞实验：

Cell lines: HUVECs Concentrations: 10 μM Incubation Time: 15 min Method: Cells are inoculated into the wells of 6-well culture plates (3 × 105 cells/well) and grown for 16 h in DMEM-based medium at 37 °C in the atmosphere of 5% CO2. After an overnight starvation (0.5% fetal bovine serum), the medium is removed, and the cells are washed with PBS and overlaid with 0.4 ml of DMEM. From this point on, all incubations are done at 25 °C. The inhibitors (SU1498, 10 μM; AG1433, 10 μM; AG1296, 25 μM; PD153035, 1 μM) are added and followed 15 min later by the growth factors: SPP, 1 μm; VEGF, 100 ng/ml; HGF, 100 ng/ml; bFGF, 10 ng/ml; EGF, 10 ng/ml. Forskolin (10 μm), a gratuitous inducer of adenylyl cyclase, is used as a control because of its known ability to enhance ERK phosphorylation. After a 10-min incubation, the medium is siphoned off, and the cells are lysed with 100 μl of lysis buffer. Samples (10 μl) of each lysate are fractionated by SDS-PAGE, and proteins are transferred to nitrocellulose and probed wit

参考文献：

1. Boguslawski G, et al. J Biol Chem. 2004, 279(7):5716-24.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.561 ml	12.803 ml	25.607 ml
5 mM	0.512 ml	2.561 ml	5.121 ml
10 mM	0.256 ml	1.28 ml	2.561 ml
50 mM	0.051 ml	0.256 ml	0.512 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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SU 1498