货号	规格	价格	上海	北京	珠海	重庆	武汉
S88092-5mg买3赠1	99.90%	￥204.00 S88092-5mg ￥204.00 现货（买3赠1）	4 4	-	-	-	-
S88092-10mg买3赠1	99.90%	￥306.00 S88092-10mg ￥306.00 现货（买3赠1）	4 4	-	-	-	-
S88092-25mg买3赠1	99.90%	￥640.00 S88092-25mg ￥640.00 现货（买3赠1）	4 4	-	-	-	-
S88092-50mg促销	99.90%	￥930.00 ￥744.00 S88092-50mg ￥744.00 现货	1 1	-	-	-	-
S88092-100mg促销	≥98%	￥1390.00 ￥1110.00 S88092-100mg ￥1110.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.

靶点：

Fatty Acid Synthase;NPC1L1;NPC1L1; FattyAcidSynthase

体内研究：

Fatostatin significantly inhibits subcutaneous C4-2B tumor growth and markedly decreases serum PSA level compared to the control group. Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.

细胞实验：

Cell lines: CHO-K1 cells. Concentrations: 20 μM. Incubation Time: 20 h. Method: On day 0,CHO-K1 cells are plated out onto a 96-well plate in medium A.On day 2,the cells are transiently cotransfected with pCMV-PLAP-BP2(513–1141),pCMV-SCAP,and pAc-β-gal,using Lipofectamine reagent.After incubation for 5 hr,the cells are washed with PBS and then incubated in medium B,in the absence or presence of fatostatin (20 μM) or sterols (10 μg/mL cholesterol and 1 μg/mL 25-hydroxycholesterol).After 20 hr of incubation,an aliquot of the medium is assayed for secreted alkaline phosphatase activity.The cells in each well are lysed and used for measurement of β-galactosidase activities.The alkaline phosphatase activity is normalized by the activity of β-galactosidase.

动物实验：

Animal Models: Obese (ob/ob) mice (C57BL/6J background). Formulation: 10% DMSO in PBS. Dosages: 30 mg/kg. Administration: intraperitoneal injection

参考文献：

1. Li X, et al. Mol Cancer Ther. 2014, 13(4):855-66. 2. Zhang Z, He J, Zhao Y, et al. Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ[J]. Acta Pharmacologica Sinica. 2020, 41(3): 373-382. 3. Kamisuki S, et al. Chem Biol. 2009, 16(8):882-92.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.664 ml	13.322 ml	26.643 ml
5 mM	0.533 ml	2.664 ml	5.329 ml
10 mM	0.266 ml	1.332 ml	2.664 ml
50 mM	0.053 ml	0.266 ml	0.533 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

Fatostatin A Hydrobromide