货号	规格	价格	上海	北京	珠海	重庆	武汉
S88108-2mg买3赠1	99.80%	￥280.00 S88108-2mg ￥280.00 现货（买3赠1）	9 9	-	-	-	-
S88108-5mg买3赠1	99.80%	￥430.00 S88108-5mg ￥430.00 现货（买3赠1）	7 7	-	-	-	-
S88108-10mg买3赠1	99.80%	￥630.00 S88108-10mg ￥630.00 现货（买3赠1）	12 >10	-	-	-	-
S88108-25mg买3赠1	99.80%	￥1230.00 S88108-25mg ￥1230.00 现货（买3赠1）	11 >10	-	-	-	-

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产品描述：

Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM. Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo

靶点：

IC50: 0.26 μM (PAR1);Protease-activatedReceptor

体内研究：

Parmodulin 2 (ML161; 5 mg/kg; IV) significantly inhibits platelet thrombus formation, with a 73% inhibition in AUC (area under the curve).Parmodulin 2 inhibits platelet thrombus formation in vivo, and it does not prolong bleeding time. Parmodulin 2 selectively inhibits platelet aggregation through Par1 and the α2A-adrenergic receptor. Animal Model: C57BL/6J wild type mice Dosage: 5 mg/kg (Pharmacokinetic Analysis) Administration: IV Result: Significantly inhibited platelet thrombus formation, with a 73% inhibition in AUC.

参考文献：

1. Gandhi DM, et al. Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells. Bioorg Med Chem. 2018 May 15;26(9):2514-2529. 2. Susanna F Gunnink, et al. Allosteric inhibition of protease activated receptor 1: a new antiplatelet therapy. 3. Aisiku O, et al. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood. 2015 Mar 19;125(12):1976-85.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.768 ml	13.842 ml	27.683 ml
5 mM	0.554 ml	2.768 ml	5.537 ml
10 mM	0.277 ml	1.384 ml	2.768 ml
50 mM	0.055 ml	0.277 ml	0.554 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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ML 161