货号	规格	价格	上海	北京	珠海	重庆	武汉
S88112-5mg买3赠1	99.24%	￥352.00 S88112-5mg ￥352.00 现货（买3赠1）	7 7	-	-	-	-
S88112-10mg买3赠1	99.24%	￥640.00 S88112-10mg ￥640.00 现货（买3赠1）	3 3	-	-	-	-
S88112-50mg买3赠1	99.24%	￥2400.00 S88112-50mg ￥2400.00 现货（买3赠1）	5 5	-	-	-	-
S88112-100mg买3赠1	99.24%	￥3360.00 S88112-100mg ￥3360.00 现货（买3赠1）	5 5	-	-	-	-

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产品描述：

Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.

靶点：

HCV Protease;Histamine Receptor;HCVProtease; HistamineReceptor

体内研究：

Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours) which is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice

细胞实验：

Clemizole hydrochloride is dissolved in DMSO and stored, and then diluted with appropriate media before use. Huh7.5 cells are maintained in DMEM supplemented with 1% L-glutamine, 1% penicillin, 1% streptomycin, 1× nonessential amino acids and 10% FBS. Cell lines are passaged twice weekly after treatment with 0.05% trypsin-0.02% EDTA and seeding at a dilution of 1:5. Subconfluent Huh7.5 cells are trypsinized and collected by centrifugation at 700 g for 5 min. The cells are then washed three times in ice-cold RNase-free PBS and resuspended at 1.5×107 cells/mL in PBS. Wild-type or mutant FL-J6/JFH-5′C19Rluc2AUbi RNA for electroporation is generated by transcription of XbaI linearized DNA templates using the T7 MEGAscript kit, followed by purification (RNA transcription and fluorescent labeling). We mixed 5 μg of RNA with 400 μL of washed Huh7.5 cells in a 2-mm-gap cuvette (BTX) and immediately pulsed (0.82 kV, five 99 μs pulses) with a BTX-830 electroporator. After a 10 min recovery at 25°C, pulsed cells are dil

参考文献：

1. Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. 2. Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96. 3. Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.069 ml	15.345 ml	30.69 ml
5 mM	0.614 ml	3.069 ml	6.138 ml
10 mM	0.307 ml	1.534 ml	3.069 ml
50 mM	0.061 ml	0.307 ml	0.614 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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