货号	规格	价格	上海	北京	珠海	重庆	武汉
S88119-5mg买3赠1	≥98%	￥170.00 S88119-5mg ￥170.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S88119-10mg买3赠1	99.70%	￥280.00 S88119-10mg ￥280.00 现货（买3赠1）	7 7	-	-	-	-
S88119-25mg买3赠1	99.70%	￥490.00 S88119-25mg ￥490.00 现货（买3赠1）	6 6	-	-	-	-
S88119-50mg买3赠1	99.70%	￥780.00 S88119-50mg ￥780.00 现货（买3赠1）	4 4	-	-	-	-
S88119-100mg买3赠1	99.70%	￥1320.00 S88119-100mg ￥1320.00 现货（买3赠1）	5 5	-	-	-	-

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产品描述：

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure

靶点：

Toxoplasma;AdrenergicReceptor

体内研究：

Guanabenz (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden. Guanabenz (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice. Guanabenz (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats. Animal Model: BALB/cJ mice Dosage: 5 mg/kg Administration: 5 mg/kg/day; i.p. ; for 3 weeks Result: Reduced the latent brain cysts in both male and female BALB/cJ mice.

参考文献：

1. Christiane Neuber, et al. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PLoS One. 2014 Jun 3;9(6):e98893. 2. Jennifer Martynowicz, et al. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. mBio. 2019 Apr 30;10(2):e00381-19. 3. T Baum, et al. Studies on the centrally mediated hypotensive activity of guanabenz. Eur J Pharmacol. 1976 May;37(1):31-44.

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.328 ml	21.638 ml	43.275 ml
5 mM	0.866 ml	4.328 ml	8.655 ml
10 mM	0.433 ml	2.164 ml	4.328 ml
50 mM	0.087 ml	0.433 ml	0.866 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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GUANABENZ