| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88184-2mg促销 |
98.10% | ￥240.00 ￥192.00 |
8 | - | - | - | - |
|
S88184-5mg促销 |
98.10% | ￥340.00 ￥272.00 |
6 | - | - | - | - |
|
S88184-10mg促销 |
98.10% | ￥520.00 ￥416.00 |
6 | - | - | - | - |
|
S88184-25mg促销 |
≥98% | ￥1150.00 ￥920.00 |
货期：2-3天 | - | - | - | - |
|
S88184-50mg |
≥98% | ￥1670.00 |
货期：2-3天 | - | - | - | - |
|
S88184-100mg |
≥98% | ￥2580.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC50 of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC50 of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | COX-1:1.44 nM (IC50);COX-2:447 nM (IC50);COX | ||||||||||||||||||||
| 体内研究： | Mofezolac (1-30 mg/kg; oral administration; once) treatment results in the suppression of writhing induced by the intraperitoneal injection of phenyl-p-benzoquinone in mice. Animal Model: Female ddY mice (4 week old, 18-27 g) injected with phenyl-p-benzoquinone (PQ) Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Oral administration; once Result: Dose-dependently suppressed the writhing induced by PQinjection in mice. | ||||||||||||||||||||
| 参考文献： | 1. K Goto, et al. Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice. Prostaglandins Other Lipid Mediat. 1998 Jul;56(4):245-54. 2. Maria Laura Pati, et al. Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability. Eur J Med Chem. 2019 Feb 15;164:59-76. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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