| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88256-5mg |
≥98% | ￥490.00 |
货期：3-5天 | - | - | - | - |
|
S88256-10mg |
≥98% | ￥820.00 |
货期：3-5天 | - | - | - | - |
|
S88256-25mg |
≥98% | ￥1650.00 |
货期：3-5天 | - | - | - | - |
|
S88256-50mg |
≥98% | ￥2640.00 |
货期：3-5天 | - | - | - | - |
|
S88256-100mg |
≥98% | ￥4290.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Glucocorticoid receptor;GlucocorticoidReceptor | ||||||||||||||||||||
| 体外研究： | The affinity of AZD5423 to the glucocorticoid receptor is high with an IC50 of 0.9 nM in a radioligand human glucocorticoid receptor assay, and selectivity towards other steroid hormone receptors is >900-fold | ||||||||||||||||||||
| 参考文献： | 1. Werkström V, et al. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581. 2. Gauvreau GM, et al. A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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