货号	规格	价格	上海	北京	珠海	重庆	武汉
S88271-1mg买3赠1	98.50%	￥590.00 S88271-1mg ￥590.00 现货（买3赠1）	8 8	-	-	-	-
S88271-5mg买3赠1	98.50%	￥1200.00 S88271-5mg ￥1200.00 现货（买3赠1）	9 9	-	-	-	-
S88271-10mg买3赠1	98.50%	￥1950.00 S88271-10mg ￥1950.00 现货（买3赠1）	6 6	-	-	-	-
S88271-25mg买3赠1	98.50%	￥3640.00 S88271-25mg ￥3640.00 现货（买3赠1）	6 6	-	-	-	-
S88271-50mg	98.50%	￥5730.00 S88271-50mg ￥5730.00 现货	5 5	-	-	-	-
S88271-100mg	≥98%	￥7760.00 S88271-100mg ￥7760.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).

靶点：

KD: 189 μM (rhMD2);TLR

体外研究：

Myeloid differentiation protein 2 (MD2) is a co-receptor of TLR4. Among those derivatives, MD2-IN-1 (compound 20) shows the strongest inhibitory effect on LPS-induced expression of both TNF-α and IL-6. Compare to the vehicle, LPS alone largely increases the amount of TLR4/MD2 complex, while pretreatment with MD2-IN-1 inhibits the increase of TLR4/MD2 complex to the vehicle level. SPR analysis shows that MD2-IN-1 exhibits recognizable binding to rhMD2 protein in a dose-dependent manner, with a KD value of 189 μM, while the KD value of xanthohumol binding to MD2 is 460 μM. Pre-treatment with different doses of MD2-IN-1 dose-dependently reduces FITC-LPS binding to MD2 in cell surface membranes, with a 65% inhibition at 10 μM in terms of mean fluorescence intensity. Pretreatment with MD2-IN-1 also dose-dependently blocks LPS-induced MAPK phosphorylation in the MPMs

体内研究：

Administration of MD2-IN-1 evidently reduces the LPS-induced increase in protein concentrations in BALF. The lung wet/dry weight ratio is markedly higher in the LPS-treated group than the control group, and MD2-IN-1 treatment reduces LPS-induced pulmonary edema. LPS also causes observable lung histopathologic changes, including areas of inflammatory infiltration, hemorrhage, interstitial edema, thickening of the alveolar wall, and lung tissue destruction. These histopathological changes are ameliorated in the MD2-IN-1 treatment group

参考文献：

1. Zhang Y, et al. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr 27;6:25130.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.79 ml	13.951 ml	27.903 ml
5 mM	0.558 ml	2.79 ml	5.581 ml
10 mM	0.279 ml	1.395 ml	2.79 ml
50 mM	0.056 ml	0.279 ml	0.558 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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