货号	规格	价格	上海	北京	珠海	重庆	武汉
S88283-2mg买3赠1	99.10%	￥450.00 S88283-2mg ￥450.00 现货（买3赠1）	5 5	-	-	-	-
S88283-5mg买3赠1	99.10%	￥690.00 S88283-5mg ￥690.00 现货（买3赠1）	6 6	-	-	-	-
S88283-10mg买3赠1	99.10%	￥1120.00 S88283-10mg ￥1120.00 现货（买3赠1）	6 6	-	-	-	-
S88283-25mg买3赠1	99.10%	￥2000.00 S88283-25mg ￥2000.00 现货（买3赠1）	3 3	-	-	-	-
S88283-50mg买3赠1	≥98%	￥3200.00 S88283-50mg ￥3200.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

靶点：

IC50: 4.9 nM (Human DP2), 7.8 nM (Mouse DP2), 4.9 nM (Guinea pig DP2), 10.4 nM (Rat DP2);ProstaglandinReceptor

体外研究：

AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. In the presence of 0.2% serum albumin, AM211 inhibits radiolabeled PGD2 binding to human, mouse, guinea pig, and rat DP2 with IC50 values of 12.2, 20.1, 22.9, and 34.2 nM, respectively. AM211 displays high selectivity for DP2 versus other receptors in the prostanoid family, with IC50 values for the inhibition of radioligand binding to human TP, IP, DP1, and FP of more than 100 μM. AM211 (100 μM) shows no activity at COX-1, COX-2 enzymes as well as PPAR family of nuclear receptor

体内研究：

AM211 (1, 10, and 30 mg/kg, p.o.) dose-dependently decreases in the number of DK-PGD2-induced peripheral blood leukocytes, with a calculated ED50 of 0.85 mg/kg. AM211 (30 mg/kg) also decreases antigen-induced pulmonary inflammation in guinea pigs. AM211 (10 mg/kg, p.o.) causes significant decrease in ovalbumin (OVA)-induced sneezing in a mouse model of allergic rhinitis

参考文献：

1. Bain G, et al. Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.998 ml	9.99 ml	19.98 ml
5 mM	0.4 ml	1.998 ml	3.996 ml
10 mM	0.2 ml	0.999 ml	1.998 ml
50 mM	0.04 ml	0.2 ml	0.4 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

AM-211