首页
订购/客服:400-666-5481

CLP 290

    
99.70%

2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate

源叶(MedMol)
S88284 一键复制产品信息
1181083-81-7
C19H21FN4O3S
404.4584432
CLP290
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S88284-5mg促销
99.70%

¥155.00 ¥139.00

5 - - - -
S88284-10mg
99.70%

¥265.00

5 - - - -
S88284-25mg
99.70%

¥530.00

4 - - - -
S88284-50mg
≥98%

¥1000.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.
靶点: Potassium Channel;PotassiumChannel
体内研究: In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons.Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.
动物实验: Morphine sulfate (50 mg/ml) was diluted in saline sterile solution immediately before injection.?Morphine or saline were subcutaneously injected twice a day (10 mg/kg;?9 a.m. 6 p.m.) in na?ve adult rats.The KCC2 enhancer CLP257 and its carbamate pro-drug CLP290 were freshly diluted in 20% 2-hydroxypropyl-β-cyclodextrin (HPCD) prior injection.CLP257 or vehicle were delivered intraperitoneally after 7 8 days of morphine or saline, as described (100 mg/kg).?CLP290 or vehicle were delivered orally by gavage twice a day for the whole duration of the morphine/saline treatment (100 mg/kg).
参考文献: 1. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870.
溶解性: Soluble  in  DMSO
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.472 ml 12.362 ml 24.724 ml
5 mM 0.494 ml 2.472 ml 4.945 ml
10 mM 0.247 ml 1.236 ml 2.472 ml
50 mM 0.049 ml 0.247 ml 0.494 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号:JS298415 货号:S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

=
×
×