货号	规格	价格	上海	北京	珠海	重庆	武汉
S88284-5mg促销	99.70%	￥155.00 ￥139.00 S88284-5mg ￥139.00 现货	5 5	-	-	-	-
S88284-10mg	99.70%	￥265.00 S88284-10mg ￥265.00 现货	5 5	-	-	-	-
S88284-25mg	99.70%	￥530.00 S88284-25mg ￥530.00 现货	4 4	-	-	-	-
S88284-50mg	≥98%	￥1000.00 S88284-50mg ￥1000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.

靶点：

Potassium Channel;PotassiumChannel

体内研究：

In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons.Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.

动物实验：

Morphine sulfate (50 mg/ml) was diluted in saline sterile solution immediately before injection.?Morphine or saline were subcutaneously injected twice a day (10 mg/kg;?9 a.m. 6 p.m.) in na?ve adult rats.The KCC2 enhancer CLP257 and its carbamate pro-drug CLP290 were freshly diluted in 20% 2-hydroxypropyl-β-cyclodextrin (HPCD) prior injection.CLP257 or vehicle were delivered intraperitoneally after 7 8 days of morphine or saline, as described (100 mg/kg).?CLP290 or vehicle were delivered orally by gavage twice a day for the whole duration of the morphine/saline treatment (100 mg/kg).

参考文献：

1. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.472 ml	12.362 ml	24.724 ml
5 mM	0.494 ml	2.472 ml	4.945 ml
10 mM	0.247 ml	1.236 ml	2.472 ml
50 mM	0.049 ml	0.247 ml	0.494 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

CLP 290

2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)