| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88307-1mg买3赠1 |
98.00% | ￥230.00 |
8 | - | - | - | - |
|
S88307-5mg买3赠1 |
98.00% | ￥560.00 |
6 | - | - | - | - |
|
S88307-10mg买3赠1 |
98.00% | ￥800.00 |
5 | - | - | - | - |
|
S88307-25mg买3赠1 |
98.00% | ￥1440.00 |
6 | - | - | - | - |
|
S88307-50mg买3赠1 |
98.00% | ￥2240.00 |
5 | - | - | - | - |
|
| 产品描述： | APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain | ||||||||||||||||||||
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| 靶点： | IC50: 280 nM (IRE1α);IRE1 | ||||||||||||||||||||
| 体外研究： | APY29 divergently modulates the RNase activity and oligomerization state of IRE1α. APY29 is exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α | ||||||||||||||||||||
| 参考文献： | 1. Wang L, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec;8(12):982-9. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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