| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88342-1mg买3赠1 |
99.90% | ￥340.00 |
9 | - | - | - | - |
|
S88342-5mg促销 |
99.90% | ￥1100.00 ￥880.00 |
6 | - | - | - | - |
|
S88342-10mg促销 |
99.90% | ￥1700.00 ￥1360.00 |
5 | - | - | - | - |
|
S88342-25mg促销 |
99.90% | ￥3300.00 ￥2640.00 |
6 | - | - | - | - |
|
| 产品描述： | BMS-813160 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC50s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation | ||||||||||||||||||||
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| 靶点： | CCR5:3.6 nM (IC50);CCR2:6.2 nM (IC50);CCR | ||||||||||||||||||||
| 体外研究： | BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. BMS-813160 shows activities to CCR2 CTX, CCR2 CD11b, CCR5 CTX and CCR5 CD11b with IC50s of 0.8, 4.8, 1.1 and 5.7 nM, respectively | ||||||||||||||||||||
| 体内研究： | BMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability. Animal Model: Human-CCR2 knock-in C57BL/6 male mice with thioglycollate injection Dosage: 10, 50 and 160 mg/kg Administration: Oral gavage; 10-160 mg/kg twice a day; for two days Result: Dose-dependently reduced inflammatory monocyte and macrophage infiltration in the peritoneum. | ||||||||||||||||||||
| 参考文献： | 1. Norman P. et al. A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of WO2011046916. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24. 2. Cherney RJ, et al. BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate. ACS Med Chem Lett. 2021 Oct 15;12(11):1753-1758. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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