货号	规格	价格	上海	北京	珠海	重庆	武汉
S88361-1mg	≥98%	￥500.00 S88361-1mg ￥500.00 3-5天	0 货期：3-5天	-	-	-	-
S88361-5mg	≥98%	￥1200.00 S88361-5mg ￥1200.00 3-5天	0 货期：3-5天	-	-	-	-
S88361-10mg	≥98%	￥2200.00 S88361-10mg ￥2200.00 3-5天	0 货期：3-5天	-	-	-	-
S88361-25mg	≥98%	￥4500.00 S88361-25mg ￥4500.00 3-5天	0 货期：3-5天	-	-	-	-
S88361-50mg	≥98%	￥6400.00 S88361-50mg ￥6400.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

靶点：

TLR

体内研究：

To test their activity in vivo, mice were orally dosed with 20 mg/kg of AT791 or E6446 and 18 hours later were challenged with 60 μg CpG1668 oligonucleotide injected subcutaneously. CpG1668-induced IL-6 production was inhibited ~50% by AT791 and almost completely by E6446. therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection

参考文献：

1. Franklin BS, et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. 2. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.162 ml	10.809 ml	21.618 ml
5 mM	0.432 ml	2.162 ml	4.324 ml
10 mM	0.216 ml	1.081 ml	2.162 ml
50 mM	0.043 ml	0.216 ml	0.432 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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计算重置

CEP-33779