货号	规格	价格	上海	北京	珠海	重庆	武汉
S88409-1mg买3赠1	99.90%	￥110.00 S88409-1mg ￥110.00 现货（买3赠1）	11 >10	-	-	-	-
S88409-5mg买3赠1	99.90%	￥260.00 S88409-5mg ￥260.00 现货（买3赠1）	10 10	-	-	-	-
S88409-10mg促销	99.90%	￥440.00 ￥352.00 S88409-10mg ￥352.00 现货	11 >10	-	-	-	-
S88409-25mg促销	99.90%	￥880.00 ￥704.00 S88409-25mg ￥704.00 现货	7 7	-	-	-	-
S88409-50mg促销	99.90%	￥1500.00 ￥1200.00 S88409-50mg ￥1200.00 现货	3 3	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).

靶点：

Apoptosis;HSP;Apoptosis; HSP

体内研究：

JG-98 (3 mg/kg) suppressed tumor growth in a HeLa xenograft model, though somewhat less effective

细胞实验：

Cell viability was determined using an MTT colorimetric assay with the following modifications. Briefly, cells (5 x 10^3 ) were plated into 96-well assay plates in 0.1 ml media and allowed to attach overnight. Cells were then treated with compound at various concentrations in 0.2 mL media. After the 72-hour incubation period, cells were washed in PBS (3 x 100 μL), and 10 μL MTT reagent was added with 100 μL fresh media. Cells were then incubated for 4 hr in a humidified chamber at 37 oC with 5% CO2. Insoluble formazan crystals were solubilized by addition of 0.1 mL detergent solution (4 hr at room temp., dark). Resulting colored solutions were then quantified at an absorbance of 570 nm

动物实验：

Briefly, one million MCF7 or HeLa cells in Matrigel were subcutaneously injected bilaterally into 6 week old NCR mice. Once tumors were established, JG-98 (3 mg/kg; n=5) or vehicle control (1:1 PBS: DMSO; n=5) was introduced interperitoneally on days 2, 4 and 6. Tumor growth (10 tumors/5 mice) was measured by caliper every other day

参考文献：

1. Li X, et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar;14(3):642-8. 2. Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11).

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0 ml	0 ml	0 ml
5 mM	0 ml	0 ml	0 ml
10 mM	0 ml	0 ml	0 ml
50 mM	0 ml	0 ml	0 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

JG98