| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88415-1mg促销 |
≥99% | ￥830.00 ￥746.00 |
7 | - | - | - | - |
|
S88415-5mg促销 |
≥99% | ￥2490.00 ￥2240.00 |
货期：3-5天 | - | - | - | - |
|
S88415-10mg促销 |
≥99% | ￥3480.00 ￥3130.00 |
货期：3-5天 | - | - | - | - |
|
S88415-25mg促销 |
≥99% | ￥6080.00 ￥5470.00 |
货期：3-5天 | - | - | - | - |
|
S88415-50mg促销 |
≥99% | ￥8500.00 ￥7650.00 |
货期：3-5天 | - | - | - | - |
|
S88415-100mg促销 |
≥99% | ￥11900.00 ￥10700.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | Fulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively. | ||||||||||||||||||||
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| 靶点： | IC50: 4 nM (human chymase enzyme), 3 nM (hamster chymase enzyme) | ||||||||||||||||||||
| 体外研究： | Fulacimstat inhibits human and hamster chymase enzyme with IC50s of 4 nM and 3 nM, respectively | ||||||||||||||||||||
| 体内研究： | Isoprenaline induces cardiac fibrosis (24.4±1.8%) in hamsters, which is reduced dose dependently by Fulacimstat (16.4±1.2%, 12.4 ± 1.3%, 10.9±1.4% at 1, 3 and 10 mg/kg respectively) and by enalapril (17.7±1.5% at 20 mg/kg). Four weeks after MI, hamster hearts show an increased end diastolic pressure, and reduce contractility and relaxation. Compared to placebo (19.3±2 mmHg), Fulacimstat at 10 mg/kg reduce significantly the end diastolic pressure (13.2±1.4 mmHg) without any effects on blood pressure or heart rate. Moreover, treatment with Fulacimstat reduce the fibrotic area and improve the cardiac response to adrenergic stimulation | ||||||||||||||||||||
| 参考文献： | 1. Hanna Tinel, et al. Abstract 13624: A Novel Chymase Inhibitor BAY 1142524 Reduces Fibrosis and Improves Cardiac Function After Myocardial Infarction in Hamster. Circulation. 2018;136:A13624. 2. Kanefendt F, et al. Pharmacokinetics, Safety, and Tolerability of the Novel Chymase Inhibitor BAY 1142524 in Healthy Male Volunteers. Clin Pharmacol Drug Dev. 2018 Jun 7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京